Leon eventually discovers that both Ada and Krauser are working with Albert Wesker, for whom both intend to secure a Plagas sample. He soon discovers that one of his former training comrades, Jack Krauser (Michael Shannon), who was believed to have been killed in a helicopter crash two years prior, is responsible for her kidnapping. After taking Ramon down, Leon meets Ada again and travels with her help to the Island.ДЄfterwards, Leon travels to a nearby island research facility, where he continues the search for Ashley. She is, however, caught again and sent to the military research island, forcing Leon battle his way through the castle before finally killing Salazar. While Leon can't get to Ashley, she must find a way to him. Leon rescues Ashley, but vows to avenge Luis' death. government, when he is killed by Saddler. When Leon finds Ashley and is about to rescue her, Luis runs in with drugs to suppress the growth of the parasite, and a sample of Dominant Species Plaga for the U.S. Leon fights his way through the underground sewer system, despite assaults by Saddler's mutated 'Novistadors'. While searching for Ashley, Leon meets Ada Wong (Maggie Q), who survived the destruction of the Umbrella underground lab and her injuries from the tyrant at the lab's self-destruct mechanism is there for the sample of the 'Dominant Species Plaga' for her enigmatic employers, the 3rd Organization, but she doesn't tell Leon about it. But Ashley starts coughing blood, which distresses her, and she runs off, and is captured. They were wrong.ДЄfter meeting yet another of Saddler's acolytes, the castle's castellan, Ramon Salazar (Thomas Brodie-Sangster), who jacks Leon's communication with Washington, Leon and Ashley travel to the center of the castle. Leon and Ashley believe they can take refuge in it until another chopper arrives. Traveling down a gondola, and facing village chief Bitores Mendez (Robert Maillet), Leon takes his false eye, and uses it on a retinal scan to open a door, which leads to the castle. After traveling through a canyon, where the two face another El Gigante.

However, Leon finds out that the helicopter has been shot down. When the attack ends, Leon and Luis separate. Meeting up with Luis once more in a cabin, they are ambushed by a seemingly never-ending crowd of Ganado.

The two escape from Saddler, and make their way to the extraction point. He tells them about the Plagas growing in their bodies. While escaping with Ashley, he meets the mastermind of Los Iluminados: Osmund Saddler (Charles Dance). On the way back Leon fights with the gigantic and ferocious, 'El Gigante'. After regaining consciousness, he obtains a key to open the church where Ashley (Carey Mulligan) is being held. Leon defeats the creature, but is severely fatigued, and collapses in a cabin. He travels across a lake where he faces a large and dangerous creature, 'Del Lago'. Unfortunately, Leon and Luis are captured, during which time Leon is injected with the parasite.ДЄfter escaping and meeting a mysterious man, only known as the Merchant (Doug Jones), who supplies Leon with ordnance and weaponry, Leon returns to his objective.

By examining SeraвЂ™s notes, Leon discovers that Los Iluminados gained control of their subjects by implanting a mind controlling parasite known as 'Las Plagas' into their bodies. In his way he meets Luis Sera (Javier Bardem), a former Los Iluminados researcher, who aids Leon on his mission. Kennedy (Chris Evans), travels to an undisclosed village in Spain where he encounters a huge contingent of unruly villagers who pledge their lives to Los Iluminados, the cult that perpetuated AshleyвЂ™s kidnapping. Now an agent for a special security agency, Leon is sent to Spain on a mission to rescue Ashley Graham (Carey Mulligan), the President's daughter, who has been kidnapped by a mysterious cult organization. Kennedy (Chris Evans), one of the few survivors of the Racoon City incident, who was recruited and trained by the US Government to become a special agent after they learned of his actions in Raccoon City.

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